Resumen de The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin

Iwona Driskell, Hisanobu Oda, Sandra Blanco, Elisabete Nascimento, Peter Humphreys, Michaela Frye

• Keratinocyte-specific ablation of the histone H4K20 methyltransferase Setd8 reveals its essential role in embryonic and postnatal skin homeostasis. Molecularly, the c-myc target gene Setd8 regulates proliferation/differentiation by controlling p63 function.