The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin

• Iwona Driskell ^[1] ; Hisanobu Oda ^[2] ; Sandra Blanco ^[1] ; Elisabete Nascimento ^[1] ; Peter Humphreys ^[1] ; Michaela Frye ^[1]
  1. [1] Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
  2. [2] Howard Hughes Medical Institute and Department of Biochemistry, New York University School of Medicine, New York, NY, USA; National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 3, 2011, págs. 616-629
• Idioma: inglés
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• Resumen

  • Keratinocyte-specific ablation of the histone H4K20 methyltransferase Setd8 reveals its essential role in embryonic and postnatal skin homeostasis. Molecularly, the c-myc target gene Setd8 regulates proliferation/differentiation by controlling p63 function.