Resumen de FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors
Elena Mancini, Alejandra Sanjuán Pla, Luisa Luciani, Susan Moore, Amit Grover, Agnes Zay, Kasper D. Rasmussen, Sidinh Luc, Daniel Bilbao, Donal O'Carroll, Sten Eirik W. Jacobsen, Claus Nerlov
During haematopoiesis, megakaryocytes and erythrocytes derive from a common precursor called preMegE. This study reports a role for the transcription factor FOG-1 in specification of preMegEs, while GATA-1 is subsequently required for erythroid-lineage commitment.
