FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors

• Elena Mancini ^[2] ; Alejandra Sanjuan-Pla ^[1] ; Luisa Luciani ^[2] ; Susan Moore ^[1] ; Amit Grover ^[1] ; Agnes Zay ^[1] ; Kasper D Rasmussen ^[2] ; Sidinh Luc ^[3] ; Daniel Bilbao ^[2] ; Donal O'Carroll ^[2] ; Sten Eirik Jacobsen ^[3] ; Claus Nerlov ^[1]
  1. [1] University of Edinburgh

     University of Edinburgh

     Reino Unido

     
  2. [2] EMBL Mouse Biology Unit, Monterotondo, Italy
  3. [3] Haemopoietic Stem Cell Laboratory, Weatherall Institute for Molecular Medicine, University of Oxford, Oxford, UK

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 2, 2011, págs. 351-365
• Idioma: inglés
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  • During haematopoiesis, megakaryocytes and erythrocytes derive from a common precursor called preMegE. This study reports a role for the transcription factor FOG-1 in specification of preMegEs, while GATA-1 is subsequently required for erythroid-lineage commitment.