Resumen de Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment

Boris Pfander, John F.X. Diffley

• Cyclin-dependent kinase phosphorylation of the replication checkpoint mediator Rad9 controls its association with Dpb11, a key activator of the yeast ATR homologue Mec1, thus conferring cell-cycle dependence to checkpoint signalling.