Elena Seiradake, Charlotte H. Coles, Pavel V. Perestenko, Karl Harlos, Robert Andrew Jeffrey McIlhinney, Alexandru Radu Aricescu, E. Yvonne Jones
NetrinGs and NetrinG-ligands (NGLs) control neuronal circuit development, and their dysregulation is associated with autism and schizophrenia. The first structures of NetrinG-NGL complexes and structure-based functional assays show that binding affinity governs the cell surface compartmentalization of NGLs.
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