Structural basis for cell surface patterning through NetrinG–NGL interactions

• Elena Seiradake ^[1] ; Charlotte H Coles ^[1] ; Pavel V Perestenko ^[2] ; Karl Harlos ^[1] ; Robert Andrew Jeffrey McIlhinney ^[2] ; Alexandru Radu Aricescu ^[1] ; Edith Yvonne Jones ^[1]
  1. [1] Wellcome Trust Centre for Human Genetics

     Wellcome Trust Centre for Human Genetics

     Oxford District, Reino Unido

     
  2. [2] University of Oxford

     University of Oxford

     Oxford District, Reino Unido

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 21, 2011, págs. 4479-4488
• Idioma: inglés
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• Resumen

  • NetrinGs and NetrinG-ligands (NGLs) control neuronal circuit development, and their dysregulation is associated with autism and schizophrenia. The first structures of NetrinG-NGL complexes and structure-based functional assays show that binding affinity governs the cell surface compartmentalization of NGLs.