Resumen de Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects

Roberto Marcucci, James Brindle, Simona Paro, Angela Casadio, Sophie Hempel, Nicholas Morrice, Andrea Bisso, Liam P Keegan, Giannino del Sal, Mary E. O’Connell

• While the essential role of the adenosine deaminase ADAR2 in RNA editing is well established, how it is regulated remains largely unknown. Here, the prolyl isomerase Pin1 and the E3 ubiquitin ligase WWP2 are shown to play a role in regulating ADAR2 localisation and stability.