Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects

• Roberto Marcucci ^[2] ; James Brindle ^[2] ; Simona Paro ^[2] ; Angela Casadio ^[2] ; Sophie Hempel ^[2] ; Nicholas Morrice ^[3] ; Andrea Bisso ^[1] ; Liam P Keegan ^[2] ; Giannino Del Sal ^[1] ; Mary A O'Connell ^[2]
  1. [1] University of Trieste

     University of Trieste

     Trieste, Italia

     
  2. [2] MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
  3. [3] The Beatson Institute for Cancer Research, Glasgow, UK

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 20, 2011, págs. 4211-4222
• Idioma: inglés
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• Resumen

  • While the essential role of the adenosine deaminase ADAR2 in RNA editing is well established, how it is regulated remains largely unknown. Here, the prolyl isomerase Pin1 and the E3 ubiquitin ligase WWP2 are shown to play a role in regulating ADAR2 localisation and stability.