Resumen de The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85

Thomas Oellerich, Vanessa Bremes, Konstantin Neumann, Hanibal Bohnenberger, Kai Dittmann, He-Hsuan Hsiao, Michael Engelke, Tim Schnyder, Facundo D. Batista, Henning Urlaub, Jürgen Wienands

• The Slp65 adaptor molecule is important for B-cell receptor signalling. Here, the interactomes of SLP65 in resting and activated B cells are resolved by mass spectrometry. A number of SLP65 interacting partners, including CIN85, continuously associate with SLP65 in a stimulation-independent manner. CIN85 recruits SLP65 to the membrane and it is required for SLP65 phosphorylation.