The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85

• Thomas Oellerich ^[3] ; Vanessa Bremes ^[3] ; Konstantin Neumann ^[3] ; Hanibal Bohnenberger ^[3] ; Kai Dittmann ^[3] ; He-Hsuan Hsiao ^[1] ; Michael Engelke ^[3] ; Tim Schnyder ^[2] ; Facundo D Batista ^[2] ; Henning Urlaub ^[1] ; Jürgen Wienands ^[3]
  1. [1] Max Planck Institute for Biophysical Chemistry

     Max Planck Institute for Biophysical Chemistry

     Landkreis Göttingen, Alemania

     
  2. [2] London Research Institute

     London Research Institute

     Reino Unido

     
  3. [3] Institute of Cellular and Molecular Immunology, Georg-August-University Göttingen, Göttingen, Germany

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 17, 2011, págs. 3620-3634
• Idioma: inglés
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  • The Slp65 adaptor molecule is important for B-cell receptor signalling. Here, the interactomes of SLP65 in resting and activated B cells are resolved by mass spectrometry. A number of SLP65 interacting partners, including CIN85, continuously associate with SLP65 in a stimulation-independent manner. CIN85 recruits SLP65 to the membrane and it is required for SLP65 phosphorylation.