Resumen de Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain

Yoichi Kosodo, Taeko Suetsugu, Masumi Suda, Yuko Mimori-Kiyosue, Kazunori Toida, Sh.A. Baba, Akatsuki Kimura, Fumio Matsuzaki

• In proliferating neural epithelia, cells undergo interkinetic nuclear migration: stereotyped cell cycle-dependent movements in the apico-basal plane. The microtubule-binding protein Tpx2 is here shown to regulate the G2-phase basal-to-apical migration, while passive displacement effects are responsible for basally directed movements.