Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain

• Yoichi Kosodo ^[1] ; Taeko Suetsugu ^[1] ; Masumi Suda ^[2] ; Yuko Mimori-Kiyosue ^[1] ; Kazunori Toida ^[2] ; Shoji A Baba ^[3] ; Akatsuki Kimura ^[4] ; Fumio Matsuzaki ^[1]
  1. [1] RIKEN Center for Developmental Biology

     RIKEN Center for Developmental Biology

     Chuo-ku, Japón

     
  2. [2] Kawasaki Medical School

     Kawasaki Medical School

     Japón

     
  3. [3] Ochanomizu University

     Ochanomizu University

     Japón

     
  4. [4] National Institute of Genetics

     National Institute of Genetics

     Japón

     

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 9, 2011, págs. 1690-1704
• Idioma: inglés
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• Resumen

  • In proliferating neural epithelia, cells undergo interkinetic nuclear migration: stereotyped cell cycle-dependent movements in the apico-basal plane. The microtubule-binding protein Tpx2 is here shown to regulate the G2-phase basal-to-apical migration, while passive displacement effects are responsible for basally directed movements.