Resumen de TGF-β regulates isoform switching of FGF receptors and epithelial–mesenchymal transition

Takuya Shirakihara, Kana Horiguchi, Keiji Miyazawa, Shogo Ehata, Tatsuhiro Shibata, Ikuo Morita, Kohei Miyazono, Masao Saitoh

• Both TGF-β and FGF signalling regulate the epithelial–mesenchymal transition. Here, TGF-β is found to promote myofibroblast differentiation, while concomitant FGF pathway activation instead drives cells towards an invasive mesenchymal fate.