TGF-β regulates isoform switching of FGF receptors and epithelial–mesenchymal transition

• Takuya Shirakihara ^[1] ; Kana Horiguchi ^[1] ; Keiji Miyazawa ^[2] ; Shogo Ehata ^[1] ; Tatsuhiro Shibata ^[3] ; Ikuo Morita ^[4] ; Kohei Miyazono ^[1] ; Masao Saitoh ^[1]
  1. [1] University of Tokyo

     University of Tokyo

     Japón

     
  2. [2] University of Yamanashi

     University of Yamanashi

     Japón

     
  3. [3] National Cancer Center Hospital

     National Cancer Center Hospital

     Japón

     
  4. [4] Department of Cellular Physiological Chemistry and Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 4, 2011, págs. 783-795
• Idioma: inglés
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• Resumen

  • Both TGF-β and FGF signalling regulate the epithelial–mesenchymal transition. Here, TGF-β is found to promote myofibroblast differentiation, while concomitant FGF pathway activation instead drives cells towards an invasive mesenchymal fate.