Resumen de Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
Andreas M. Grabrucker, Mary J. Knight, Christian Proepper, Jürgen Bockmann, Marisa Joubert, Magali Rowan, G. Ulrich Nienhaus, Craig C. Garner, J. U. Bowie, Michael R. Kreutz, Eckart D. Gundelfinger, Tobias M. Boeckers
ProSAP/Shank are scaffolding proteins that localize to the postsynaptic density (PSD). This study shows that Zn2+ ions directly regulate the localization and recruitment of Shank/ProSAP1/2 to PSDs to facilitate synapse formation and maturation.
