Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation

• Andreas M Grabrucker ^[3] ; Mary J Knight ^[4] ; Christian Proepper ^[5] ; Juergen Bockmann ^[5] ; Marisa Joubert ^[4] ; Magali Rowan ^[1] ; G UIrich Nienhaus ^[6] ; Craig C Garner ^[1] ; Jim U Bowie ^[4] ; Michael R Kreutz ^[2] ; Eckart D Gundelfinger ^[7] ; Tobias M Boeckers ^[5]
  1. [1] Stanford University

     Stanford University

     Estados Unidos

     
  2. [2] Leibniz Institute for Neurobiology

     Leibniz Institute for Neurobiology

     Landeshauptstadt Magdeburg, Alemania

     
  3. [3] Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
  4. [4] Department of Chemistry and Biochemistry, UC Los Angeles, CA, USA
  5. [5] Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
  6. [6] Institute of Applied Physics and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
  7. [7] Department of Neurochemistry/Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 3, 2011, págs. 569-581
• Idioma: inglés
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• Resumen

  • ProSAP/Shank are scaffolding proteins that localize to the postsynaptic density (PSD). This study shows that Zn2+ ions directly regulate the localization and recruitment of Shank/ProSAP1/2 to PSDs to facilitate synapse formation and maturation.