Resumen de Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing

Eric Huntzinger, Joerg E. Braun, Susanne Heimstädt, Latifa Zekri, Elisa Izaurralde

• Previous studies have suggested that the mechanism of miRNA-mediated silencing may differ between human and Drosophila cells. Here, a direct comparison demonstrates that the mechanism is conserved and the GW182–PABP interaction is required for silencing in vivo.