Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing

• Eric Huntzinger ^[1] ; Joerg E Braun ^[1] ; Susanne Heimstädt ^[1] ; Latifa Zekri ^[1] ; Elisa Izaurralde ^[1]
  1. [1] Max Planck Institute for Developmental Biology

     Max Planck Institute for Developmental Biology

     Landkreis Tübingen, Alemania

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 29, Nº. 24, 2010, págs. 4146-4160
• Idioma: inglés
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• Resumen

  • Previous studies have suggested that the mechanism of miRNA-mediated silencing may differ between human and Drosophila cells. Here, a direct comparison demonstrates that the mechanism is conserved and the GW182–PABP interaction is required for silencing in vivo.