Resumen de Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90

Shan Yang, Xuxu Sun, Binggang Xiang, Hui Cang, Xunlei Kang, Yuying Chen, Hui Li, Guiying Shi, Edward T H Yeh, Beilei Wang, Xiangrui Wang, Jing Yi

• SENP3 was recently implicated as redox sensor affecting hypoxia-inducible factor-1-dependent transcription under conditions of mild oxidative stress. In a novel mechanism, the chaperone Hsp90 selectively stabilizes oxidized SENP3 by protecting it from ubiquitination mediated by the co-chaperone CHIP.