Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90

• Shan Yan ^[1] ; Xuxu Sun ^[1] ; Binggang Xiang ^[1] ; Hui Cang ^[1] ; Xunlei Kang ; Yuying Chen ^[1] ; Hui Li ^[1] ; Guiying Shi ^[1] ; Edward T H Yeh ^[2] ; Beilei Wang ^[1] ; Xiangrui Wang ^[1] ; Jing Yi ^[1]
  1. [1] Shanghai Jiao Tong University

     Shanghai Jiao Tong University

     China

     
  2. [2] University of Texas MD Anderson Cancer Center

     University of Texas MD Anderson Cancer Center

     Estados Unidos

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 29, Nº. 22, 2010, págs. 3773-3786
• Idioma: inglés
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• Resumen

  • SENP3 was recently implicated as redox sensor affecting hypoxia-inducible factor-1-dependent transcription under conditions of mild oxidative stress. In a novel mechanism, the chaperone Hsp90 selectively stabilizes oxidized SENP3 by protecting it from ubiquitination mediated by the co-chaperone CHIP.