Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin: Report of two cases

• Eduardo Flores-Villalba ^[1] ; Carlos Rodriguez-Montalvo ^[1] ; Gabriela Arredondo-Saldaña ^[2] ; Francisco Bosques-Padilla ^[1] ; Tania Zertuche-Maldonado ^[2] ; Landy Torre-Flores ^[2]
  1. [1] Hospital San Jose-Tec de Monterrey.México
  2. [2] School of Medicine and Health Sciences of Tec Salud. Monterrey, México
• Localización: Revista Española de Enfermedades Digestivas, ISSN-e 2340-4167, ISSN 1130-0108, Vol. 108, Nº. 4, 2016, págs. 228-230
• Idioma: inglés
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• Resumen

  • Gilbert’s syndrome is a benign condition characterized by asymptomatic sporadic episodes of jaundice, due to a mild unconjugated hyperbilirubinemia caused by a deficiency in bilirubin glucoronidation. Under certain physiologic or pathologic events, bilirubin level rises but according to literature it does not reach out more than 3 mg/dl. We report 2 cases of Gilbert’s syndrome, genetically tested, which presented with bilirubin levels above 6 mg/dl without any trigger or coexisting condition. In conclusion, bilirubin levels higher than 6 mg/dl in Gilbert syndrome are rare, hemolytic and other metabolism diseases must be ruled out, and genetic testing may be necessary in some cases