Resumen de No-Go’ing Back: Co-opting RVB-2 to Control HIV-1 Gene Expression and Immune Response

Valerie Le Sage, Alessandro Cinti, Andrew J. Mouland

• Production of infectious HIV-1 particles requires viral envelope (Env) glycoprotein incorporation. Although, the precise mechanism remains elusive, interaction between Env and the matrix (MA) domain of Gag plays a central role. Work by Mu and colleagues demonstrates how the Env–MA interaction regulates gag mRNA stability and Gag expression levels.