No-Go’ing Back: Co-opting RVB-2 to Control HIV-1 Gene Expression and Immune Response

• Autores: Valerie Le Sage, Alessandro Cinti, Andrew J. Mouland
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 23, Nº. 10, 2015, págs. 593-595
• Idioma: inglés
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• Resumen

  • Production of infectious HIV-1 particles requires viral envelope (Env) glycoprotein incorporation. Although, the precise mechanism remains elusive, interaction between Env and the matrix (MA) domain of Gag plays a central role. Work by Mu and colleagues demonstrates how the Env–MA interaction regulates gag mRNA stability and Gag expression levels.