Resumen de Use of 15N Label in Organic Synthesis and Spectroscopy.: Part I: Preparation of 15N-Labeled tert-Butylamine

Erach R. Talaty, Christopher A. Boese, Sanni M. Adewale, Mohammed S. Ismail, Frank A. Provenzano, Melissa J. Utz

• The preparation of 15N-labeled tert-butylamine involves the conversion of the correspondingly labeled potassium cyanide into the 15N-labeled tert-butylformamide via the Ritter reaction in 85% yield, followed by hydrolysis with either aqueous sodium hydroxide or hydrochloric acid. The NMR spectra of the compounds provide a valuable opportunity for discussing several important topics in NMR spectroscopy, such as cis-trans isomerism due to restricted rotation and 15N coupling. Comparison of the IR spectra of the labeled and unlabeled compounds permits a forum for discussing the theory of vibrational frequencies.