Use of 15N Label in Organic Synthesis and Spectroscopy.: Part I: Preparation of 15N-Labeled tert-Butylamine
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Erach R. Talaty [1] ; Christopher A. Boese [1] ; Sanni M. Adewale [1] ; Mohammed S. Ismail [1] ; Frank A. Provenzano [1] ; Melissa J. Utz [1]
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[1] Wichita State University
Wichita State University
City of Wichita, Estados Unidos
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- Localización: Journal of chemical education, ISSN 0021-9584, Vol. 79, Nº 2, 2002, pág. 221
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
The preparation of 15N-labeled tert-butylamine involves the conversion of the correspondingly labeled potassium cyanide into the 15N-labeled tert-butylformamide via the Ritter reaction in 85% yield, followed by hydrolysis with either aqueous sodium hydroxide or hydrochloric acid. The NMR spectra of the compounds provide a valuable opportunity for discussing several important topics in NMR spectroscopy, such as cis-trans isomerism due to restricted rotation and 15N coupling. Comparison of the IR spectra of the labeled and unlabeled compounds permits a forum for discussing the theory of vibrational frequencies.
