Developing New Antibiotics with Combinatorial Biosynthesis
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Nicola L. Pohl [1]
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[1] Iowa State University
Iowa State University
Township of Franklin, Estados Unidos
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- Localización: Journal of chemical education, ISSN 0021-9584, Vol. 77, Nº 11 (November), 2000, págs. 1421-1421
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Polyketide synthases (PKSs), a class of enzymes found in soil bacteria that produce antibiotics such as erythromycin, string together acetate units using basic organic reactions. The manipulation of the sequence of these reactions at the genetic level has resulted in an alteration of the corresponding chemical structure of the antibiotic produced by the bacteria. This process, called combinatorial biosynthesis, allows the generation of many presently unknown complex structures that can be tested for antibacterial activity, thereby contributing to the race against antibiotic-resistant infectious bacteria.
