Resumen de MicroRNA-15a down-regulation is associated with adverse prognosis in human glioma
T. Xie, P. Liu, L. Chen, Z. Chen, Y. Luo, X. Chen, Y. Feng, X. Luo
Objective The aim of this study was to investigate whether miR-15a has prognostic relevance in human gliomas.
Methods The expression levels of miR-15a were analyzed in glioma surgical resection tissues by microarray and quantitative real-time PCR. Survival analysis by the Kaplan–Meier method was performed to assess prognostic significance.
Results Downregulation of miR-15a was detected in most primary gliomas, which was confirmed by qRT-PCR analysis. Additionally, the down-regulation of miR-15a was significantly associated with the WHO grade (P = 0.003), the low KPS (P = 0.027), time to recurrence (P = 0.044) and the poor OS (P = 0.046). Using Kaplan–Meier analysis, a comparison of survival curves of low versus high expresser of miR-15a revealed a highly significant difference in OS (P = 0.001) and DFS (P = 0.006), which suggested that low expression of miR-15a is associated with a worse prognosis. Multivariate analyses showed that miR-15a expression was independent risk factors predicting OS [Hazard ratio (HR), 7.52; 95 % confidence interval (CI), 2.63–21.47; P = 0.002] and DFS [HR, 11.56; 95 % CI, 5.17–25.96; P < 0.001] in glioma.
Conclusions These findings indicated for the first time that the expression of miR-15a is significantly correlated with prognosis in glioma patients, suggesting that the miR-15a may serve as independent prognostic marker.
