Enzymatic Resolution and Separation of Secondary Alcohols Based on Fatty Esters as Acylating Agents

• Carlos M. Monteiro ^[1] ; Carlos A. M. Afonso ^[1] ; Nuno M. T. Lourenço ^[1]
  1. [1] Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 87, Nº 4 (April), 2010, págs. 423-425
• Idioma: inglés
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• Resumen

  • The enzymatic resolution of rac-1-phenylethanol using ethyl myristate as acylating agent and solvent and Candida antarctica lipase B (CAL-B) as biocatalyst was demonstrated with catalyst and medium reuse. Both enantiomers of 1-phenylethanol were isolated by sequential enzymatic reactions and product distillations. From the first enzymatic reaction, (S)-1-phenylethanol was isolated with a 41% yield and 80% enantiomeric excess, and from the second enzymatic reaction, (R)-1-phenylethanol was isolated with a 56% yield and 63% enantiomeric excess.