Resumen de Using Proteins in a Bioinorganic Laboratory Experiment:: Iron Loading and Removal from Transferrin
Erin E. Battin, Ashley Lawhon, Julia L. Brumaghim, David H. Hamilton
With the increasing availability of metalloproteins it is now possible to incorporate them into bioinorganic laboratory experiments. Thus, we have developed a laboratory experiment where students use UV–vis spectroscopy to determine the rate of iron removal from transferrin by a well-known, commercially-available iron chelating drug, Deferiprone. Students gain experience in both chemical and biological laboratory techniques, while assessing the efficacy of a drug that is physiologically relevant to humans.
