Comparing the Traditional with the Modern:: A Greener, Solvent-Free Dihydropyrimidone Synthesis

• Autores: Evangelos Aktoudianakis, Elton Chan, Amanda R. Edward, Isabel Jarosz, Vicki Lee, Leo Mui, Sonya S. Thatipamala, Andrew P. Dicks
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 86, Nº 6 (June), 2009, págs. 730-732
• Idioma: inglés
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• Resumen

  • A microscale organic synthesis experiment is outlined where students undertake both a "traditional" and "modern" Biginelli preparation of a dihydropyrimidone, within the same three-hour session. Each method is straightforward, appropriate as part of a mid-level undergraduate laboratory, and performed individually or between a pair of students. Emphasis is placed on comparing approaches from a green chemistry perspective. The class probes concepts of catalytic reactivity, solvent-free synthesis, atom economy, and energy consumption to assess green improvements made by employing the modern strategy.