A Two-Step Synthesis of Virstatin, A Virulence Inhibitor of Vibrio cholerae

• Autores: Chriss E. McDonald
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 86, Nº. 4 (April), 2009, págs. 482-483
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Virstatin, an N-butanoic acid substituted naphthalimide, inhibits the ability of Vibrio cholerae to cause disease. A three-week experiment involving synthesis, purification, and spectral characterization of this compound is described. This experiment is appropriate for organic chemistry. It has been performed with three lab sections of about fifteen students each and can be executed in three laboratory periods each lasting three hours.