Myeloperoxidase Is an Early Biomarker of Inflammation and Cardiovascular Risk in Prepubertal Obese Children

• Autores: Josune Olza, Concepción María Aguilera García, Mercedes Gil Campos, María Rosaura Leis Trabazo, María Gloria Bueno Lozano, Mª Dolores Martínez-Jiménez, Ramón Cañete Estrada, Rafael Tojo Sierra, Luis A. Moreno Aznar, Ángel Gil i Origüen
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 35, Nº. 11, 2012, págs. 2373-2376
• Idioma: inglés
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• Resumen

  • Obesity is associated with a state of chronic low-grade inflammation. Myeloperoxidase (MPO) plays an important role in the initiation and progression of acute and chronic inflammatory diseases, such as cardiovascular disease (CVD). The objectives of the current study were to evaluate plasma MPO levels in prepubertal obese children and to determine whether MPO could be an early biomarker of inflammation and CVD risk. In a prospective multicenter case-control study paired by age and sex of 446 Caucasian prepubertal children ages 6-12 years, 223 normal-weight and 223 obese children were recruited. Blood pressure, waist circumference, weight, and height were measured. In addition to MPO, glucose, insulin, metabolic lipid parameters, oxidized low-density lipoproteins, adiponectin, leptin, resistin, C-reactive protein (CRP), interleukin 6, tumor necrosis factor ?, matrix metalloproteinase-9 (MMP-9), and plasminogen activator inhibitor 1 were determined. We found that MPO was elevated in prepubertal obese children and that this enzyme was associated with such proinflammatory and cardiovascular risk biomarkers as CRP, MMP-9, and resistin. Insulin resistance calculated by the homeostatic assessment model was the best predictor of MPO. MPO is an early biomarker of inflammation associated with CVD risk in obese children at the prepubertal age. [PUBLICATION ABSTRACT]