Resumen de Bone marrow transplantation for beta-thalassemia
Marrow transplantation from HLA-identical siblings has been increasingly adopted for therapy of non-malignant conditions.
The first successful transplant in b-thalassaemia, was performed by Thomas et al. in 1981 in an untransfused 14-months old child. This patient, now aged 18 years, is the longest surviving patient who is definitely cured from a genetic disease by bone marrow transplantation. At the same time a 14-year old thalassemic patient who had recived 150 cell transfusions was transplanted in Pesaro but he had recurrence of thalassemia after rejection of the graft.
