Resumen de BIK/NBK gene as potential marker of prognostic and therapeutic target in breast cancer patients

Eunice López-Muñoz, Adelina Hernández-Zarco, Normand García-Hernández, Isabel Alvarado Cabrero, Gelasio Zarco-Espinosa, Fabio Salamanca Gómez, Diego Arenas-Aranda

• Purpose The purpose of this study is to determine the association between the BIK/NBK gene expression and estrogen receptor alpha expression.

  Materials and methods We determined the association of BIK/NBK gene expression by real time quantitative reverse transcription polymerase chain reaction and estrogen receptor alpha expression by immunohistochemistry in samples of breast cancer tissue.

  Results We found a statistically significant correlation of BIK/NBK gene expression with the estrogen receptor alpha expression (? = 0.751, p = 0.004). For verify differences of BIK/NBK gene expression among ER?+ and ER?- breast cancer tissues, Mann�Whitney U test was performed, obtaining significant differences.

  Conclusions BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients according to the estrogen receptor alpha expression.