BIK/NBK gene as potential marker of prognostic and therapeutic target in breast cancer patients

• Autores: Eunice López-Muñoz, Adelina Hernández-Zarco, Normand García-Hernández, Isabel Alvarado Cabrero, Gelasio Zarco-Espinosa, Fabio Salamanca Gómez, Diego Arenas-Aranda
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 14, Nº. 8, 2012, págs. 586-591
• Idioma: inglés
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• Resumen

  • Purpose The purpose of this study is to determine the association between the BIK/NBK gene expression and estrogen receptor alpha expression.

    Materials and methods We determined the association of BIK/NBK gene expression by real time quantitative reverse transcription polymerase chain reaction and estrogen receptor alpha expression by immunohistochemistry in samples of breast cancer tissue.

    Results We found a statistically significant correlation of BIK/NBK gene expression with the estrogen receptor alpha expression (? = 0.751, p = 0.004). For verify differences of BIK/NBK gene expression among ER?+ and ER?- breast cancer tissues, Mann�Whitney U test was performed, obtaining significant differences.

    Conclusions BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients according to the estrogen receptor alpha expression.