Resumen de Long-term results and prognostic factors of patients with cervical carcinoma treated with concurrent chemoradiotherapy
Anna Reig Castillejo, Ismael Membrive Conejo, Palmira Foro Arnalot, Javier Sanz Latiesas, Nuria Rodríguez Núñez, Joan Lozano, Martí Lacruz, J. Quera Jordana, E. Fernández Velilla, Manuel Ignacio Algara López
Aims and background To evaluate the predictive factors of recurrence in cervical cancer treated with radical radiochemotherapy.
Methods A retrospective analysis of 56 women was performed. Response was assessed using the RECIST response. Overall survival and disease-free survival curves were estimated by the Kaplan-Meier method and the Cox proportional hazards model was used to analyse predictors of recurrence.
Results Local recurrence was documented in 16 patients and distant metastases in 15. The Kaplan-Meier survival probabilities were 95.1±6.4% at 3 years and 80.4±13.1% at 5 years and the Kaplan-Meier curve values for disease-free survival were 60.3±14.3% at 3 years and 53.0±15.7% at 5 years. Thirty-five patients were alive and 21 patients died, 19 from metastatic disease and 2 from other causes. Complete response after chemoradiation therapy, squamous cell carcinoma and tumour size ?4 cm were significantly associated with outcome. In the Cox regression model, tumour size >4 cm (hazard ratio 7.48; 95% CI 2.71�20.6; p<0.001) and partial response (hazard ratio 7.09; 95% CI 2.82�17.8; p<0.001) were predictive factors for disease-free survival and partial response (hazard ratio 3.7; 95% CI 1.3�10.1; p<0.001) and non-squamous cell carcinoma (hazard ratio 3.5; 95% CI 1.2�9.7; p<0.001) were predictive factors for overall survival.
Conclusions Non-squamous histology and partial response were independent prognostic factors for overall survival and tumour size and partial response were independent prognostic variables for 5-year disease survival.
