Long-term results and prognostic factors of patients with cervical carcinoma treated with concurrent chemoradiotherapy

• Autores: Anna Reig Castillejo, Ismael Membrive Conejo, Palmira Foro Arnalot, Javier Sanz Latiesas, Nuria Rodríguez Núñez, Joan Lozano, Martí Lacruz, J. Quera Jordana, E. Fernández Velilla, Manuel Ignacio Algara López
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 13, Nº. 7, 2011, págs. 504-508
• Idioma: inglés
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• Resumen

  • Aims and background To evaluate the predictive factors of recurrence in cervical cancer treated with radical radiochemotherapy.

    Methods A retrospective analysis of 56 women was performed. Response was assessed using the RECIST response. Overall survival and disease-free survival curves were estimated by the Kaplan-Meier method and the Cox proportional hazards model was used to analyse predictors of recurrence.

    Results Local recurrence was documented in 16 patients and distant metastases in 15. The Kaplan-Meier survival probabilities were 95.1±6.4% at 3 years and 80.4±13.1% at 5 years and the Kaplan-Meier curve values for disease-free survival were 60.3±14.3% at 3 years and 53.0±15.7% at 5 years. Thirty-five patients were alive and 21 patients died, 19 from metastatic disease and 2 from other causes. Complete response after chemoradiation therapy, squamous cell carcinoma and tumour size ?4 cm were significantly associated with outcome. In the Cox regression model, tumour size >4 cm (hazard ratio 7.48; 95% CI 2.71�20.6; p<0.001) and partial response (hazard ratio 7.09; 95% CI 2.82�17.8; p<0.001) were predictive factors for disease-free survival and partial response (hazard ratio 3.7; 95% CI 1.3�10.1; p<0.001) and non-squamous cell carcinoma (hazard ratio 3.5; 95% CI 1.2�9.7; p<0.001) were predictive factors for overall survival.

    Conclusions Non-squamous histology and partial response were independent prognostic factors for overall survival and tumour size and partial response were independent prognostic variables for 5-year disease survival.