Resumen de Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation
Dmitri V. Krysko, Patrizia Agostinis, Olga Krysko, Abhishek D. Garg, Claus Bachert, Bart N. Lambrecht, Peter Vandenabeele
Cell death and injury often lead to release or exposure of intracellular molecules called damage-associated molecular patterns (DAMPs) or cell death-associated molecules. These molecules are recognized by the innate immune system by pattern recognition receptors � the same receptors that detect pathogen-associated molecular patterns, thus revealing similarities between pathogen-induced and non-infectious inflammatory responses. Many DAMPs are derived from the plasma membrane, nucleus, endoplasmic reticulum and cytosol. Recently, mitochondria have emerged as other organelles that function as a source of DAMPs. Here, we highlight the significance of mitochondrial DAMPs and discuss their contribution to inflammation and development of human pathologies.
