Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

• Autores: Dmitri V. Krysko, Patrizia Agostinis, Olga Krysko, Abhishek D. Garg, Claus Bachert, Bart N. Lambrecht, Peter Vandenabeele
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 32, Nº. 4, 2011, págs. 157-164
• Idioma: inglés
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• Resumen

  • Cell death and injury often lead to release or exposure of intracellular molecules called damage-associated molecular patterns (DAMPs) or cell death-associated molecules. These molecules are recognized by the innate immune system by pattern recognition receptors � the same receptors that detect pathogen-associated molecular patterns, thus revealing similarities between pathogen-induced and non-infectious inflammatory responses. Many DAMPs are derived from the plasma membrane, nucleus, endoplasmic reticulum and cytosol. Recently, mitochondria have emerged as other organelles that function as a source of DAMPs. Here, we highlight the significance of mitochondrial DAMPs and discuss their contribution to inflammation and development of human pathologies.