Resumen de Oleoyl-estrone treatment reduces the volume of white adipose tissue cells in the rat.
C. Cabot, Maria del Mar Grasa Martínez, José Antonio Fernández López, Marià Alemany Lamana
It has been showed that oleoyl-estrone treatment diminishes the fat content of lean and obese rats. In this work it has been determined that oleoyl-estrone treatment diminishes white adipose tissue cell size. Zucker Fa/? rats were implanted in the left carotid with miniosmotic pumps filled with either a fat stable emulsion (control) or supplemented with oleoyl-estrone (3.5 mmol/kg day, treated). After 14 days treatment, samples of inguinal subcutaneous and periovaric white adipose tissue were obtained. The results demonstrate that oleoyl-estrone significantly reduces the width and volume of adypocytes in both locations, which suggests that oleoyl-estrone induces a general increase in lipolysis.
