Oleoyl-estrone treatment reduces the volume of white adipose tissue cells in the rat.

• Autores: C. Cabot, Maria del Mar Grasa Martínez, José Antonio Fernández López, Marià Alemany Lamana
• Localización: Journal of physiology and biochemistry, ISSN-e 1877-8755, ISSN 1138-7548, Vol. 56, Nº. 4, 2000, pág. 369
• Idioma: inglés
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• Resumen

  • It has been showed that oleoyl-estrone treatment diminishes the fat content of lean and obese rats. In this work it has been determined that oleoyl-estrone treatment diminishes white adipose tissue cell size. Zucker Fa/? rats were implanted in the left carotid with miniosmotic pumps filled with either a fat stable emulsion (control) or supplemented with oleoyl-estrone (3.5 mmol/kg day, treated). After 14 days treatment, samples of inguinal subcutaneous and periovaric white adipose tissue were obtained. The results demonstrate that oleoyl-estrone significantly reduces the width and volume of adypocytes in both locations, which suggests that oleoyl-estrone induces a general increase in lipolysis.