SEOM–TTCC clinical guidelines for the treatment of head and neck cancer (2025)

• Virginia Arrazubi ^[1] ; Lara Iglesias ^[2] ; Marc Oliva ^[7] ; Pedro Pérez Segura ^[8] ; Jordi Rubió-Casadevall ^[9] ; Gemma Bruixola ^[3] ; Alberto Carral ^[4] ; Beatriz Castelo ^[5] ; Beatriz Cirauqui ^[10] ; Antonio Rueda ^[6]
  1. [1] Hospital Universitario de Navarra

     Hospital Universitario de Navarra

     Pamplona, España

     
  2. [2] Hospital Universitario 12 de Octubre

     Hospital Universitario 12 de Octubre

     Madrid, España

     
  3. [3] Universitat de València

     Universitat de València

     Valencia, España

     
  4. [4] Complexo Hospitalario Universitario da Coruña

     Complexo Hospitalario Universitario da Coruña

     A Coruña, España

     
  5. [5] Hospital Universitario La Paz

     Hospital Universitario La Paz

     Madrid, España

     
  6. [6] Hospital Universitario Virgen de la Victoria

     Hospital Universitario Virgen de la Victoria

     Málaga, España

     
  7. [7] Medical Oncology Department, Institutd’InvestigacióBiomèdica de Bellvitge (IDIBELL), Institut Català d’Oncologia (ICO) L’Hospitalet, Barcelona, Spain
  8. [8] Medical Oncology Department, Hospital Clínico San Carlos, IdISC (Instituto de Investigación del Hospital Clínico San Carlos), Madrid, Spain
  9. [9] Medical Oncology Department. Catalan Institute of Oncology, Hospital Josep Trueta, Oncogirpro Group, Biomedical Research Institute of Girona (IDIBGI), Girona, Spain
  10. [10] Medical Oncology Department, Catalan Institute of Oncology (ICO), Badalona, Spain

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 28, Nº. 6, 2026, págs. 2056-2067
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Squamous cell carcinoma of the lip, oral cavity, oropharynx, hypopharynx, and larynx comprises the ninth most common cancer in Spain. While alcohol and tobacco use have long been the primary etiological factors, the role of human papillomavirus (HPV) in oropharyngeal cancer is increasing. Diagnoses and relapses should always be discussed by an expert multidisciplinary team. For localized stages, surgery or radiotherapy should be used as single-modality treatments, while locoregional stages require combined modality approaches. In the case of recurrent or metastatic disease, curative intent should be considered for patients with local recurrence or oligometastatic disease, while systemic treatment is recommended for all other cases. These guidelines, developed by the authors on behalf of the Spanish Society of Medical Oncology (SEOM) and the Spanish Group for the Treatment of Head and Neck Tumors (TTCC), review available evidence and provide expert recommendations based on the current literature.