Clinical & translational oncology

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  Año 2026, Vol. 28, Número 6

  • EDITORIAL

    • Climate disasters and cancer care: the Valencia DANA as a case for system resilience

      Javier David Benítez Fuentes, Victoria García Samblás, Mónica Maria Guillot Morales, Patricia Palacios Ozores, Ana Ruiz Casado, J. Torres Jiménez, María Vieito Villar, Regina Gironés Sarrió

      págs. 1947-1950

      

  • REVIEW ARTICLE

    • Recent advances in diagnostic and therapeutic approaches for pulmonary enteric adenocarcinoma

      Ya Guo, Heng Zhang, Bin Zhang, Yunbin Gao, Hui Li, Haibo Zhao, Qing Qing Yu

      • Resumen

      págs. 1951-1960

      

    • Esophageal neuroendocrine carcinoma: molecular insights, diagnostic advances, and emerging treatment strategies

      Xi Wen Wu, Yu Du, Yan Jiao

      • Resumen

      págs. 1961-1970

      

    • Immune–microbiota crosstalk in colorectal cancer: mechanistic pathways, biomarkers, and translational therapeutics

      Pallavi Shekar, Sushma Pradeep, Chandan Shivamallu, Akila Prashant, Prashant Vishwanath

      • Resumen

      págs. 1971-1985

      

    • Integrins as key regulators in tumor perineural invasion: mechanisms and clinical implications

      Yuanyuan Li, Xiaoli Cao, Mei Wang

      • Resumen

      págs. 1986-1997

      

    • VPS9D1-AS1: a critical oncogenic long non-coding RNA in human malignancies

      Bing Wang, Huaming Hu, Tingting Yu, Wenqian Tang, Lei Luo

      • Resumen

      págs. 1998-2013

      

    • Emerging strategies to reduce the side effects of CAR-T cell therapy: focusing on gene editing and nanotechnology

      Jinxin Dong, Denis Andreevich Nikolenko, Shuxrat Boymuradov, Lilya Garifulina, Elnaz Khodabandehloo

      • Resumen

      págs. 2014-2040

      

    • Impact of social determinants on the development, diagnosis, and treatment of cancer: recommended public health interventions

      Regina Gironés Sarrió, Javier David Benítez Fuentes, Victoria García Samblás, Mónica Maria Guillot Morales, Patricia Palacios Ozores, Ana Ruiz Casado, J. Torres Jiménez, María Vieito Villar

      • Resumen

      págs. 2041-2055

      

  • CLINICAL GUIDES IN ONCOLOGY

    • SEOM–TTCC clinical guidelines for the treatment of head and neck cancer (2025)

      Virginia Arrazubi Arrula, Lara Iglesias Docampo, Marc Oliva Bernal, Pedro Pérez Segura, J. Rubió Casadevall, Gema Bruixola Campos, Alberto Carral Maseda, Beatriz Castelo Fernández, Beatriz Cirauqui Cirauqui, Antonio Rueda Domínguez

      • Resumen

      págs. 2056-2067

      

  • RESEARCH ARTICLE

    • CCR5 expression defines the functional heterogeneity of tumor-infiltrating CD8+ T cells and predicts enhanced antitumor immunity and favorable prognosis in non-small cell lung cancer

      Yilong Li, Kaiyuan Zhang, Xue-Lian Wang, Weiping Yao, Wenjing Fei, Keyu Cheng, Guichun Huang, Yan Li

      • Resumen

      págs. 2068-2085

      

    • Prognostic value of postoperative circulating tumor DNA for recurrence-free survival in resected non-small cell lung cancer: a systematic review and meta-analysis

      Atta Ullah Khan, Intizor Avazmetova, Mukhayya Ruzieva, Barno Matchanova, Asilbek Dauletbaev, Erkin Bilalov, Muhammad Ibrahim

      • Resumen

      págs. 2086-2098

      

    • Serum cancer testis antigen MAGEA3-IgG serves as a diagnostic biomarker in lung adenocarcinoma

      Shuyu Huang, Yuhan Gan, Ruifang Zhong, Siying Wang, Yanli Kang, Jinhua Chen, Falin Chen, Liangyuan Chen, Jianbin You

      • Resumen

      págs. 2099-2108

      

    • Development and validation of a nomogram for predicting the probability of medication adherence to adjuvant endocrine therapy in breast cancer patients: a predictive modeling study

      Dong Liu, Haiyan Xu

      • Resumen

      págs. 2109-2117

      

    • Pharmacovigilance study and development of a clinical decision flowchart for personalized selection of trastuzumab, T-DXd, and T-DM1 in breast cancer patients

      Xiaohu Yang, Xiaomei Pei, Chunli Song, Lingti Kong

      • Resumen

      págs. 2118-2134

      

    • Real-world incidence and risk of myelodysplastic syndrome and acute myeloid leukemia secondary to PARP inhibitors in ovarian cancer

      Javier Corazón Villanueva, Cristina González Pérez, Ainhoa Elisa Arenaza Peña, Gloria Marquina Ospina, Antonio Casado Herráez, Rafael Sánchez del Hoyo

      • Resumen

      págs. 2135-2142

      

    • Folate receptor alpha in platinum-resistant ovarian cancer: prevalence in a multicenter Polish cohort and review of the evidence

      Jędrzej Borowczak, Justyna Durślewicz, Monika Durzyńska, Jakub Cheliński, Maria Filipek, Marek Zdrenka, Łukasz Szylberg

      • Resumen

      págs. 2143-2149

      

    • Multi-omics analysis reveals that knockdown of IMPA2 induces apoptosis in cervical cancer cells through ROS/MYC/CDK1 signaling

      Xinyi Wu, Bingqi Wang, Lei Liu, Zhenni Chen, Min Wang

      • Resumen

      págs. 2150-2160

      

    • Therapeutic efficacy and oncological prognosis of ypTNM 0-I gastric cancer after neoadjuvant therapy: a multicenter propensity-score matched study in China

      Hao Cui, Yuyuan Lu, Huiguang Ren, Liqiang Song, Zhen Yuan, Yuchen Liu, Rui Li, Lin Chen, Canrong Lu, Jianxin Cui, Bo Wei

      • Resumen

      págs. 2161-2173

      

    • Bayesian selection of lipidome dynamics features for a K-nearest neighbors (KNN) classifier model of tumor response in patients with advanced gastrointestinal adenocarcinoma undergoing systemic treatment

      Vicente Valentí Moreno, Javier Ramos, Laura Fernández Sénder, Óscar Villuendas, Begoña Rodríguez, Eugenia Sopena Bert, Marta Peña, Carlos Alonso Villaverde

      • Resumen

      págs. 2174-2182

      

    • Silencing of MAT2A inhibits gastric cancer cell proliferation, migration, and invasion through activation of the p53 pathway

      Yao Du, Kong Xian Li, Liang Bo You, Jiang Nan Zhang, Qi Chen, Hui Xiong, Jun Fu Wang, Zhi Yang Zhou, Shun Zhang

      • Resumen

      págs. 2183-2197

      

    • Adjuvant anlotinib plus TACE in hepatocellular carcinoma with postoperative high-risk recurrence: a single-arm, multi-center, phase II study

      Zheng Wang, Lei Zhang, Xin Zheng, Dong Zhang, Xue Yang, Kedong Xu, Jie Tao, Xiaojing Song, Jian Ma, Zheng Wu

      • Resumen

      págs. 2198-2207

      

    • Conversion therapy using transarterial chemoembolization plus tislelizumab for unresectable hepatocellular carcinoma: effects on tumor necrosis and anti-tumor immune response

      Qihang Yao, Guangwen Chen, Yang Yu, Zeping Chen, Xiao An, Xueqian Xie, Qingguo Wang, Desheng Chen, Hongcheng Sun

      • Resumen

      págs. 2208-2218

      

    • Clinical and prognostic implications of RAS mutations in metastatic colorectal cancer

      Evrim Ataca, Merve Keskinkilic, Sulen Sarioglu, Yasemin Basbinar, Tugba Yavuzsen

      • Resumen

      págs. 2219-2228

      

    • Single-cell transcriptomic analysis reveals cellular heterogeneity and prognostic subtypes in colorectal cancer

      Huizhen Han, Yuan Gao, Yuxing Zhao, Jiahong Wu, Jia Chen, Jinling He, Hong Bai, Liang Qiao, Yali Ren, Lei Sun

      • Resumen

      págs. 2229-2245

      

    • Immunohistochemical evaluation of EGFR protein expression and microvascular density reveals an angiogenic signature in Tunisian patients with metastatic colorectal cancer

      Amira Jaballah Gabteni, Ines Ben Ayed, Hamza Yaiche, Nadia Ben Jemii, Dorra Wider, Monia Ardhaoui, Emna Fehri, Afifa Maaloul, Essia Habbechi, Emna Ennaifer, Haifa Tounsi

      • Resumen

      págs. 2246-2258

      

    • SYT8 as a potential prognostic biomarker and therapeutic predictor in colorectal cancer: insights from multi-cohort transcriptomic analyses

      Li feng Li, Qin Hao, Jing Fan, Guizhen Gao, Miao Chen, Xu Gao, Rigetu Zhao, Hao Yang, Zhenfei Wang

      • Resumen

      págs. 2259-2272

      

    • Clinical utility of longitudinal circulating tumor DNA analysis in metastatic colorectal cancer patients receiving palliative chemotherapy

      Chung Ryul Oh, Ji Young Lee, Jeong Eun Kim, Ha Ra Jun, Sun Young Kim, Tae Won Kim, Jihun Kim, Sung Min Chun, Yong Sang Hong

      • Resumen

      págs. 2273-2285

      

    • Investigating the role of inflammatory bowel disease-associated gene expression in oral cancer using single-cell RNA sequencing

      Yongwei Cheng, Zhenyin Liu, Shifeng Xie, Ningyi Zhang, Liang Guo, Yujin Wu, Yuan Liao, Yunkai Dai

      • Resumen

      págs. 2286-2300

      

    • miR-185 in salivary extracellular vesicles for early diagnosis of malignant transformation in oral leukoplakia: a clinical study

      Qian Xia, Sen Yang, Meitong Liu, Ziyu Wang, Jiaqi Wang, Yongxiang Zhou, Yu Tian, Hongjian Wang, Shuang Ren, Yao Liu, Xiaobing Guan

      • Resumen

      págs. 2301-2313

      

    • Single-cell and bulk transcriptome analysis reveals the impact of inflammatory microglia on prognosis and immunotherapy response in primary glioblastoma

      Ziadoon Alyaqoobi, Yin He, Xiaosheng Wang

      • Resumen

      págs. 2314-2334