Efficacy of Proton Pump Inhibitors in GERD Grades A to D:: Symptom Relief and Endoscopic Healing Outcomes

• Khan, H. ^[1] ; Ullah, H. ^[2] ; Aslam, M. ^[1] ; Kamran Hassan, M. ^[1] ; Khan, D. ^[1] ; Ali, L. ^[1]
  1. [1] Hospìtal Peshawar
  2. [2] Qazi Hussain Ahmed Medical Complex
• Localización: Revista Latinoamericana de la Papa, ISSN 1019-6609, ISSN-e 1853-4961, Vol. 28, Nº. 2, 2024, págs. 65-72
• Idioma: inglés
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• Resumen

  • Background: Gastroesophageal reflux disease (GERD) is a common condition managed primarily with proton pump inhibitors (PPIs). However, the therapeutic response may vary with disease severity.

    Objective: To evaluate the effectiveness of standard-dose PPI therapy across GERD grades A to D in terms of symptom relief and endoscopic healing. Study Design : A Prospective observational Study. Place and Duration of study . Department Of Gastroenterology MTI, Lady Reading Hospital Peshawar Pakistan from jan 2023 to dec 2023 Methods: This prospective observational study enrolled 120 patients diagnosed with GERD based on clinical and endoscopic criteria. Patients received omeprazole 40 mg once daily for 8 weeks. Symptom scoring (GERD-Q) and endoscopic grading (LA classification) were conducted before and after treatment. Outcomes were analyzed using chi-square testing.

    Results: Symptom relief was observed in 93.3% (Grade A), 86.8% (Grade B), 72.4% (Grade C), and 52.2% (Grade D) (p = 0.0015). Endoscopic healing occurred in 90.0% (Grade A), 81.6% (Grade B), 65.5% (Grade C), and 39.1% (Grade D) (p = 0.00023).

    Conclusion: PPIs are highly effective in Grades A and B but significantly less so in Grades C and D. Individualized treatment strategies should be based on GERD severity