Regulation and function of silayltransferases in pancreatic cancer
- Autores: Sònia Bassagañas Puigdemont
- Directores de la Tesis: Rosa Peracaula Miró (dir. tes.)
- Lectura: En la Universitat de Girona ( España ) en 2014
- Idioma: inglés
- Tribunal Calificador de la Tesis: Pilar Navarro Medrano (presid.), Radka Fahey (voc.), María Salomé Pinho (voc.)
- Materias:
- Enlaces
- Tesis en acceso abierto en: TDX
- Resumen
Changes in the expression of Lewis-type glycan antigens, especially a predominance of sialyl-Lewis x (SLex) structure, and the glycosyltransferases involved in its synthesis, correlate with pancreatic cancer invasive and metastatic capacities. This Doctoral Thesis has focused on the involvement of sialylated determinants on key stages of pancreatic cancer tumourigenesis, such as cell-extracellular matrix adhesion and cell-cell adhesion, and invasion; and also on the influence of glycosylation on the function of membrane glycoproteins involved in these processes, such as ?2?1 integrin and E-cadherin.In addition, this study also describes that pancreatic tumour cells take advantage of the inflammatory environment that accompanies the tumour.It shows that proinflammatory cytokines regulate the cell expression of specific sialyltransferase and fucosyltransferase genes that contribute to the biosynthesis of Lewis-type and sialylated determinants, and thus may contribute to accelerate the tumour progression.
