A Bioinformatics Study of Protein Conformational Flexibility and Misfolding: a Sequence, Structure and Dynamics Approach

• Autores: Vladimir Espinosa Angarica
• Directores de la Tesis: Javier Sancho Sanz (dir. tes.)
• Lectura: En la Universidad de Zaragoza ( España ) en 2014
• Idioma: inglés
• Tribunal Calificador de la Tesis: Milagros Medina Trullenque (presid.), Juan Fernández Recio (secret.), Bruno Contreras Moreira (voc.)
• Enlaces
  • Tesis en acceso abierto en: Zaguán
• Resumen

  • This PhD Thesis titled "A Bioinformatics Study of Protein Conformational Flexibility and Misfolding: a Sequence, Structure and Dynamics Approach" comprises the results and conclusions obtained by us from the study of three different but somehow related research projects, covering aspects of the phenomenon of protein local conformational instability, its relationship with protein function, evolvability and aggregation, and the effect of genetic variations on protein conformational instability related to Conformational Diseases. These projects include the prediction of putative prion proteins in complete proteomes and the study of prion biology from a genomic perspective, the prediction of conformationally unstable protein regions and the existence of a structural framework for linking conformational instability to folding and function, and the establishment of a rationale for assessing the connection among mutations and disease phenotypes in Conformational Diseases.