Contribució de l'estat nutricional matern i de la funció placentària sobre el desenvolupament del retard de creixement intrauterí

• Autores: Pere Cavallé i Busquets
• Directores de la Tesis: Michelle M. Murphy (dir. tes.)
• Lectura: En la Universitat Rovira i Virgili ( España ) en 2013
• Idioma: catalán
• Tribunal Calificador de la Tesis: Joaquin Escribano Subías (presid.), Ramón Deulofeu Piquet (secret.), Elena Carreras Moratonas (voc.)
• Materias:
  • Ciencias médicas
    • Ciencias clínicas
      • Ginecología
    • Patología
      • Patología cardiovascular
• Enlaces
  • Tesis en acceso abierto en: TDX
• Resumen

  • OBJECTIVES: We investigated whether early pregnancy hyperhomocysteinemiais a biomarker of pathological fetoplacental Doppler or intrauterine growth retardation (IUGR). METHODS: A nested case-control study with a group of cases based onpopulation birthweightcurves (IUGR-Pop) and another group with customisedcurves(IUGR-Cus) was performed. RESULTS: 43 cases were matched with 161 controls in the IUGR-Pop group, and 145 cases with 63 controls in the group IUGR-Cus. Hyperhomocysteinemia was defined as plasma homocysteine above the 90th percentile and was associated with reduced birth weight, increased resistance of the uterine arteries, increased risk of pathological umbilical Doppler (OR = 3.1), IUGR-Poprisk (OR=8.2) andIUGR-Cus risk (OR=4.9). CONCLUSION : Early pregnancy hyperhomocysteinemiais associated with reduced birth weight, altered feto-placental Doppler function and increased IUGR risk in the two populations studied .