Effects of polyphenols and omega-3 pufas on hepatic oxidative stress

• Autores: Anabel Fernández Iglesias
• Directores de la Tesis: Miquel Mulero Abellán (dir. tes.), María Josepa Salvadó Rovira (dir. tes.)
• Lectura: En la Universitat Rovira i Virgili ( España ) en 2013
• Idioma: catalán
• Tribunal Calificador de la Tesis: Jean Max Rouanet (presid.), Begoña Muguerza Marquínez (secret.), Jordi García (voc.)
• Calificación: Sobresaliente Cum Laude
• Materias:
  • Ciencias de la vida
    • Biología celular
      • Cultivo celular
  • Ciencias médicas
    • Ciencias de la nutrición
      • Enfermedades de la nutrición
  • Ciencias tecnológicas
    • Tecnología de los alimentos
      • Antioxidantes en los alimentos
• Enlaces
  • Tesis en acceso abierto en: TDX
• Resumen

  • Over the past years it has been described the important role of oxidative stress in the Metabolic Stress related manifestations, specifically in the obesity. It is well known that agents that reduce oxidative stress represent an important tool to reduce the obesity-induced complications such as hepatic steatosis. In this sense, flavonoids are described as antioxidant molecules, due to their scavenging properties. Moreover, omega-3 PUFAs are considered effective in the treatment and prevention of several chronic diseases. Therefore, the principal aim of this thesis was to study the antioxidant effects of flavonoids and n-3 PUFAs, as well as the possible additive effects of two compounds together. These studies were developed under several oxidative stress conditions (metabolic, chemical) both in vitro and in vivo. It has been demonstrated the importance of using nutritional supplements in different oxidative stress conditions.