Genetic characterization of cdk1 in mouse development and homeostasis; A novel dichotomy between stem and committed mitotic cell cycles

• Autores: Catherine Evangeline Symonds
• Directores de la Tesis: Mariano Barbacid Montalbán (dir. tes.), David Santamaría Velilla (codir. tes.), Federico Mayor Menéndez (tut. tes.)
• Lectura: En la Universidad Autónoma de Madrid ( España ) en 2015
• Idioma: español
• Tribunal Calificador de la Tesis: Manuel Serrano Marugán (presid.), Marcos Malumbres (secret.), Javier León Serrano (voc.), Sergio Moreno Pérez (voc.), Ángel Rodríguez Nebreda (voc.)
• Materias:
  • Ciencias de la vida
    • Biología molecular
• Enlaces
  • Tesis en acceso abierto en: Biblos-e Archivo
• Resumen

  • Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle progression and transcription control. For this reason, CDKs have long been considered attractive therapeutic targets to treat hyperproliferative diseases such as cancer. Yet, the number of Cdks has significantly increased during evolution. My laboratory han been implicated in the genetic characterization of the CDK family with the aim of identifying essential and redundant functions among the diferente members. (extracto del informe del doctor D. Mariano Barbacid Montalbán).